2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

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Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Isoform Specific Products:

Phosphodiesterase (PDE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-19420
    UK 357903
    		Inhibitor
    UK 357903 is a selective inhibitor for phosphodiesterase 5 (PDE5), with IC50s of 1.7 and 714 nM, for PDE5 and PDE6. UK 357903 exhibits vasodilatory effects on the mesenteric and hindlimb vascular beds, and is potential for ameliorating erectile dysfunction.
    UK 357903
  • HY-12085R
    Apremilast (Standard)
    		Inhibitor
    Apremilast (Standard) is the analytical standard of Apremilast. This product is intended for research and analytical applications. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC50 of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC50 of 104 nM.
    Apremilast (Standard)
  • HY-W787896
    PDE4-IN-25
    		Inhibitor
    PDE4-IN-25 (compound 12) is a potent inhibitor of PDE4，with the IC50 of 0.1 μM. PDE4-IN-25 plays an important role in inflammatory diseases research.
    PDE4-IN-25
  • HY-106358R
    Andolast free base (Standard)
    		Inhibitor
    Andolast (free base) (Standard) is the analytical standard of Andolast (free base). This product is intended for research and analytical applications. Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma.
    Andolast free base (Standard)
  • HY-12348
    LEO 29102
    		Inhibitor
    LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC50 value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis.
    LEO 29102
  • HY-B0004R
    Doxofylline (Standard)
    		Inhibitor
    Doxofylline (Standard) is the analytical standard of Doxofylline. This product is intended for research and analytical applications. Doxofylline is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm.
    Doxofylline (Standard)
  • HY-131100S
    Homo Sildenafil-d5
    		Inhibitor
    Homo Sildenafil-d5 is the deuterium labeled Homo Sildenafil. Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor[1][2].
    Homo Sildenafil-d<sub>5</sub>
  • HY-133991
    Desethyl sildenafil
    Desethyl Sildenafil (Sildenafil impurity C) is the impurity of Sildenafil (HY-15025). Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
    Desethyl sildenafil
  • HY-131764
    2'-O-MB-cGMP sodium
    		Inhibitor
    2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium is a cyclic GMP-specific phosphodiesterase inhibitor with an I50 value of 35 µM. 2'-O-MB-cGMP (2′-O-Monobutyryl-cGMP) sodium inhibits Ca2+ dependent phosphodiesterase hydrolysis using cAMP or cGMP as substrate.
    2'-O-MB-cGMP sodium
  • HY-164685
    T-0156 free base
    		Inhibitor
    T-0156 free base is a potent and selective phosphodiesterase type 5 (PDE5) inhibitor. T-0156 free base specifically inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) by PDE5 in a competitive manner (IC50=0.23 nM). T-0156 free base inhibits PDE6 (IC50=56 nM) and has low potencies against PDE1, PDE2, PDE3, and PDE4 (IC50>10 μM). T-0156 free base enhances the nitric oxide (NO)/cGMP pathway.
    T-0156 free base
  • HY-B0327A
    Irsogladine maleate
    		Inhibitor
    Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder.
    Irsogladine maleate
  • HY-117838
    Phosphodiesterase 10-IN-2
    		Inhibitor
    Phosphodiesterase 10-IN-2 (THPP-4) is an oral active phosphodiesterase 10A (PDE10A) inhibitor with the Ki of 4.5 nM. Phosphodiesterase 10-IN-2 can be used for study of schizophrenia.
    Phosphodiesterase 10-IN-2
  • HY-103167
    CGH2466 dihydrochloride
    		Inhibitor
    CGH 2466 dihydrochloride is an orally active adenosine A1, A2B and A3 receptor antagonist with the IC50 values of 19 nM, 21 nM, and 80 nM respectively. CGH 2466 dihydrochloride inhibits p38 MAPK (IC50 = 187~ 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). CGH 2466 dihydrochloride displays potent anti-inflammatory effects both in vitro and in vivo, and can be used for research on asthma and chronic obstructive pulmonary disease (COPD).
    CGH2466 dihydrochloride
  • HY-90009R
    Nortadalafil (Standard)
    		Inhibitor
    Nortadalafil (Standard) is the analytical standard of Nortadalafil. This product is intended for research and analytical applications. Nortadalafil , a new tadalafil (HY-90009A) analogue detected in health foods, is a PDE5 inhibitor. Nortadalafil is used in the research of erectile dysfunction (ED). Nortadalafil can be formed by closing the diketopiperazine ring in high yield. Nortadalafil is promising for research of pulmonary arterial hypertension[4].
    Nortadalafil (Standard)
  • HY-18253R
    Udenafil (Standard)
    		Inhibitor
    Udenafil (Standard) is the analytical standard of Udenafil. This product is intended for research and analytical applications. Udenafil (DA8159) is a potent, selective and orally active phosphodiesterase type 5 (PDE5) inhibitor. Udenafil also inhibits cGMP hydrolysis and can be used for erectile dysfunction research.
    Udenafil (Standard)
  • HY-131100R
    Homo Sildenafil (Standard)
    		Inhibitor
    Homo Sildenafil (Standard) is the analytical standard of Homo Sildenafil. This product is intended for research and analytical applications. Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor.
    Homo Sildenafil (Standard)
  • HY-106306
    Laprafylline
    		Inhibitor
    Laprafylline (S 9795), a xanthine derivative, is a bronchodilator. Laprafylline has potent anti-bronchoconstrictive effects, inhibiting action on mast cell degranulation and phosphodiesterase (PDE) activity (IC50 of 6 μM).
    Laprafylline
  • HY-12318R
    IBMX (Standard)
    		Inhibitor
    IBMX (Standard) is the analytical standard of IBMX. This product is intended for research and analytical applications. IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively.
    IBMX (Standard)
  • HY-B0204R
    Pimobendan (Standard)
    		Inhibitor
    Pimobendan (Standard) is the analytical standard of Pimobendan. This product is intended for research and analytical applications. Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
    Pimobendan (Standard)
  • HY-N14662
    Griseolic acid B
    		Inhibitor
    Griseolic acid B (7′-Desoxygriseolic acid) has the activity of inhibiting cyclic adenosine monophosphate (cAMP) phosphodiesterase [EC 3.1.4.17] with an IC50 of 0.16 μM.
    Griseolic acid B
Cat. No. Product Name / Synonyms Application Reactivity
Phosphodiesterase (PDE) Isoform Comparison

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